Latrunculin A

Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration[1][2][3][4][5][6].

Product Specifications

CAS Number

[76343-93-6]

Product Name Alternative

LAT-A

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Arp2/3 Complex

Type

Natural Products

Related Pathways

Cytoskeleton

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/latrunculin-a.html

Concentration

237.2 μM * 1 mL in Ethanol

Purity

98.9

Solubility

10 mM in DMSO

Smiles

O=C1SC[C@@H]([C@]2(O)O[C@]3([H])CC[C@H](C)/C=C\C=C\CC/C(C)=C\C(O[C@@](C3)([H])C2)=O)N1

Molecular Formula

C22H31NO5S

Molecular Weight

421.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Fujiwara I, et al. Latrunculin A Accelerates Actin Filament Depolymerization in Addition to Sequestering Actin Monomers. Curr Biol. 2018 Oct 8;28 (19) :3183-3192.e2.|[2]Coué M, et al. Inhibition of actin polymerization by latrunculin A. FEBS Lett. 1987 Mar 23;213 (2) :316-8.|[3]Khalid A El Sayed, et al. Latrunculin A and its C-17-O-carbamates inhibit prostate tumor cell invasion and HIF-1 activation in breast tumor cells. J Nat Prod. 2008 Mar;71 (3) :396-402.|[4]Anke Doller, et al. The cytoskeletal inhibitors latrunculin A and blebbistatin exert antitumorigenic properties in human hepatocellular carcinoma cells by interfering with intracellular HuR trafficking. Exp Cell Res. 2015 Jan 1;330 (1) :66-80.|[5]Hiroo Konishi, et al. Latrunculin a has a strong anticancer effect in a peritoneal dissemination model of human gastric cancer in mice. Anticancer Res. 2009 Jun;29 (6) :2091-7.|[6]Liang Ma, et al. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 2015 Jan;25 (1) :24-38.