Latrunculin A
Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration[1][2][3][4][5][6].
Product Specifications
CAS Number
76343-93-6
Product Name Alternative
LAT-A
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Arp2/3 Complex
Type
Natural Products
Related Pathways
Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/latrunculin-a.html
Concentration
237.2 μM * 1 mL in Ethanol
Purity
98.9
Solubility
10 mM in DMSO
Smiles
O=C1SC[C@@H]([C@]2(O)O[C@]3([H])CC[C@H](C)/C=C\C=C\CC/C(C)=C\C(O[C@@](C3)([H])C2)=O)N1
Molecular Formula
C22H31NO5S
Molecular Weight
421.55
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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