T338C Src-IN-1

T338C Src-IN-1 is a potent mutant-Src T338C inhibitor; exhibited the most potent inhibition of T338C (IC50=111 nM) relative to WT c-Src (10-fold increase) .

Product Specifications

CAS Number

[1351926-90-3]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Src

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/T338C-Src-IN-1.html

Solubility

10 mM in DMSO

Smiles

NC1=C2C(N(C(C)C)N=C2CC3=CC(NS(=O)(C=C)=O)=CC=C3)=NC=N1

Molecular Formula

C17H20N6O2S

Molecular Weight

372.44

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Garske AL, et al. Chemical genetic strategy for targeting protein kinases based on covalent complementarity. Proc Natl Acad Sci U S A. 2011 Sep 13;108 (37) :15046-52.