(S) - (-) -5-Fluorowillardiine

(S) - (-) -5-Fluorowillardiine is a potent and specific AMPAR agonist.

Product Specifications

CAS Number

[140187-23-1]

Product Name Alternative

(5S) -Fluorowillardiine; (S) -5-Fluorowillardiine

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/_S_-_-_-5-Fluorowillardiine.html

Solubility

10 mM in DMSO

Smiles

OC([C@@H](N)CN1C=C(F)C(NC1=O)=O)=O

Molecular Formula

C7H8FN3O4

Molecular Weight

217.15

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Hawkinson JE, et al. Effects of thiocyanate and AMPA receptor ligands on (S) -5-fluorowillardiine, (S) -AMPA and (R, S) -AMPA binding. Eur J Pharmacol. 1997 Jun 25;329 (2-3) :213-21.|[2]Kessler M, et al. Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators. Brain Res. 2006 Mar 3;1076 (1) :25-41.|[3]Rembach A, et al. Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS. J Neurosci Res. 2004 Aug 15;77 (4) :573-82.