Pifithrin-β
Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.
Product Specifications
CAS Number
[60477-34-1]
Product Name Alternative
PFT β; Cyclic Pifithrin-α
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pifithrin-_beta_.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(C2=CN3C(SC4=C3CCCC4)=N2)C=C1
Molecular Formula
C16H16N2S
Molecular Weight
268.38
References & Citations
[1]Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19 (5) :1649-57.|[2]Fernández-Cruz ML, et al. Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β. Life Sci. 2011 Apr 25;88 (17-18) :774-83.|[3]Da Pozzo E, et al. p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells. ACS Chem Neurosci. 2014 May 21;5 (5) :390-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
FASEB J. 2021 Feb;35 (2) :e21325.|Front Cell Dev Biol. 2020 Jul 29;8:703.|Front Immunol. 2020 Feb 20;8:75.|Front Mol Biosci. 2021 Aug 19;8:697457.|Int J Mol Med. 2021 Jul;48 (1) :122.|Int J Mol Sci. 2023 Jul 17;24 (14) :11554.|iScience. 2024 Jun 4;27 (7) :110144.|J Virol. 2025 Aug 29:e0052925.|PLoS One. 2018 Sep 20;13 (9) :e0203833. |Sci Rep. 2025 Sep 29;15 (1) :33534.|bioRxiv. 2025 March 21.|Blood Cells Mol Dis. 2024 Jan:104:102798.|Cancer Cell Int. 2023 Sep 28;23 (1) :221.|Cell Biol Int. 2025 Jul;49 (7) :852-864.|Cell Biol Toxicol. 2023 Oct;39 (5) :2011-2032.|Cell Commun Signal. 2022 Sep 5;20 (1) :96.|Heliyon. 2024 May 19.|Life Sci. 2021 Sep 1:280:119698.|mBio. 2024 Oct 30:e0213724.|Nat Commun. 2025 Feb 25;16 (1) :1774.
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