AGN 205327
AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766/734/32 nM for RARα/β/γ respectively; no inhibition on RXR. IC50 value: 3766/734/32 nM for RARα/β/γ Target: RAR agonist
Product Specifications
CAS Number
[2070018-29-8]
UNSPSC
12352005
Target
Autophagy; RAR/RXR
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/agn-205327.html
Solubility
10 mM in DMSO
Smiles
CC1(C)CCC(C)(C)C2=C1C=CC(/C(C3=CC4=CC(C(O)=O)=CC=C4N3)=N\O)=C2
Molecular Formula
C24H26N2O3
Molecular Weight
390.47
References & Citations
[1]Preferential binding of synthetic retinoid analogs to subtypes of RAR.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16685/AGN-205327-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16685/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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