IRL-1620

IRL-1620 is a potent and selective endothelin receptor type B (ETB) agonist with a Ki of 16 pM.

Product Specifications

CAS Number

[142569-99-1]

UNSPSC

12352209

Hazard Statement

H302, H312, H332

Target

Endothelin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/IRL-1620.html

Purity

99.69

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC(CCC(O)=O)=O)=O)=O)=O)=O)=O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](C)C(N[C@@H](CC3=CN=CN3)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C86H117N17O27

Molecular Weight

1820.95

Precautions

H302, H312, H332

References & Citations

[1]Takai M, et al. A potent and specific agonist, Suc-[Glu9, Ala11,15]-endothelin-1 (8-21), IRL 1620, for the ETB receptor. Biochem Biophys Res Commun. 1992 Apr 30;184 (2) :953-9.|[2]Briyal S, et al. Stimulation of endothelin B receptors by IRL-1620 decreases the progression of Alzheimer's disease. Neuroscience. 2015 Aug 20;301:1-11.