Uprosertib hydrochloride
Uprosertib hydrochloride (GSK2141795 hydrochloride) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively.
Product Specifications
CAS Number
[1047635-80-2]
Product Name Alternative
GSK2141795 (hydrochloride)
UNSPSC
12352005
Target
Akt
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GSK2141795-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(C2=C(Cl)C=NN2C)=C(Cl)O1)N[C@@H](CC3=CC=C(F)C(F)=C3)CN.Cl
Molecular Formula
C18H17Cl3F2N4O2
Molecular Weight
465.71
References & Citations
[1]Pachl F, et al. Characterization of a chemical affinity probe targeting Akt kinases. J Proteome Res. 2013 Aug 2;12 (8) :3792-800.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Akt1; Akt2; Akt3
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