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Uprosertib hydrochloride

Uprosertib hydrochloride (GSK2141795 hydrochloride) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively.

Product Specifications

CAS Number

1047635-80-2

Product Name Alternative

GSK2141795 (hydrochloride)

UNSPSC

12352005

Target

Akt

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GSK2141795-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(C2=C(Cl)C=NN2C)=C(Cl)O1)N[C@@H](CC3=CC=C(F)C(F)=C3)CN.Cl

Molecular Formula

C18H17Cl3F2N4O2

Molecular Weight

465.71

References & Citations

[1]Pachl F, et al. Characterization of a chemical affinity probe targeting Akt kinases. J Proteome Res. 2013 Aug 2;12 (8) :3792-800.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

Akt1; Akt2; Akt3

Frequently Asked Questions

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