GW311616 (hydrochloride)

GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC50 value of 22 nM and Ki value of 0.31 nM[1].

Product Specifications

CAS Number

[197890-44-1]

Product Name Alternative

GW311616A

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Elastase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gw311616-hydrochloride.html

Purity

98.84

Solubility

H2O : 100 mg/mL (ultrasonic) |DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1[C@@H](C(C)C)[C@@](N(C(/C=C/CN2CCCCC2)=O)CC3)([H])[C@]3([H])N1S(=O)(C)=O.[H]Cl

Molecular Formula

C19H32ClN3O4S

Molecular Weight

433.99

Precautions

H315, H319, H335

References & Citations

[1]Ohbayashi H, et al. Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11 (7) :965-80.|[2]Jiang KL, et al. Neutrophil elastase and its therapeutic effect on leukemia cells. Mol Med Rep. 2015 Sep;12 (3) :4165-4172.|[3]Macdonald SJ, et al. The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate. Bioorg Med Chem Lett. 2001 Apr 9;11 (7) :895-8.