WHI-P180 (hydrochloride)
WHI-P180 (Janex 3) is a multi-kinase inhibitor; inhibits RET, KDR and EGFR with IC50s of 5 nM, 66 nM and 4 μM, respectively.
Product Specifications
CAS Number
153437-55-9
Product Name Alternative
Janex 3 hydrochloride
UNSPSC
12352005
Target
EGFR; RET; VEGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/whi-p180-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
COC1=CC2=NC=NC(NC3=CC=CC(O)=C3)=C2C=C1OC.[H]Cl
Molecular Formula
C16H16ClN3O3
Molecular Weight
333.77
References & Citations
[1]Newton R, et al. The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity. Eur J Med Chem. 2016 Apr 13;112:20-32.|[2]Ghosh S, et al. 4-[3-Bromo-4-hydroxyphenyl) amino]-6,7-dimethoxyquinazolin-1-ium chloride methanol solvateand 4-[ (3-hydroxyphenyl) amino]-6,7-dimethoxy-1-quinazolinium chloride. Acta Crystallogr C. 2001 Jan;57 (Pt 1) :76-8.|[3]Chen CL, et al. Pharmacokinetics and biologic activity of the novel mast cell inhibitor, 4- (3-hydroxyphenyl) -amino-6,7-dimethoxyquinazoline in mice. Pharm Res. 1999 Jan;16 (1) :117-22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; VEGFR2/KDR/Flk-1
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