Istaroxime
Istaroxime (PST2744) is a potent inhibitor of Na+, K+-ATPase with IC50 of 0.11 μM.
Product Specifications
CAS Number
203737-93-3
Product Name Alternative
PST2744
UNSPSC
12352211
Target
Na+/K+ ATPase
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Istaroxime.html
Solubility
10 mM in DMSO
Smiles
O=C1CC[C@@]2([H])[C@]3([H])CC([C@@]4([H])C/C(CC[C@]4(C)[C@@]3([H])CC[C@@]21C)=N/OCCN)=O
Molecular Formula
C21H32N2O3
Molecular Weight
360.49
References & Citations
[1]Gobbini M, et al. Novel analogues of istaroxime, a potent inhibitor of Na+, K+-ATPase: synthesis and structure-activity relationship. J Med Chem. 2008 Aug 14;51 (15) :4601-8.|[2]Gobbini M, et al. Novel analogues of Istaroxime, a potent inhibitor of Na (+), K (+) -ATPase: Synthesis, structure-activity relationship and 3D-quantitative structure-activity relationship of derivatives at position 6 on the androstane scaffold. Bioorg Med Ch|[3]Micheletti R, et al. Pharmacological profile of the novel inotropic agent (E, Z) -3- ((2-aminoethoxy) imino) androstane-6,17-dione hydrochloride (PST2744) . J Pharmacol Exp Ther. 2002 Nov;303 (2) :592-600.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Citation 01
Nat Commun. 2025 Aug 29;16 (1) :8074.|PNAS Nexus. 2023 Dec 22;3 (1) :pgad453.|Biochem Pharmacol. 2020 Oct;180:114122.|Biochem Pharmacol. 2023 May:211:115516.|Front Pharmacol. 2020 Dec 14:11:606097.|J Am Heart Assoc. 2021 Jul 20;10 (14) :e018833.
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