UR-PI376

UR-PI376 is a potent and selective histamine H4 receptor (H4R) agonist with a pEC50 value of 7.47. UR-PI376 shows negligible hH1R and hH2R activities and moderate inverse agonistic activity at the hH3R[1].

Product Specifications

CAS Number

[1192559-94-6]

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ur-pi376.html

Smiles

N#CN/C(NCCSC1=CC=CC=C1)=N\CCCCC2=CN=CN2

Molecular Formula

C17H22N6S

Molecular Weight

342.46

References & Citations

[1]Patrick Igel, et al. Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists. J Med Chem. 2009 Oct 22;52 (20) :6297-313.