Ripasudil (free base)
Ripasudil free base (K-115 free base) is a specific inhibitor of ROCK, with IC50s of 19 and 51 nM for ROCK2 and ROCK1, respectively.
Product Specifications
CAS Number
223645-67-8
Product Name Alternative
K-115 (free base)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/K-115-free-base.html
Solubility
10 mM in DMSO
Smiles
FC1=CN=CC2=C1C(S(N3CCCNC[C@@H]3C)(=O)=O)=CC=C2
Molecular Formula
C15H18FN3O2S
Molecular Weight
323.39
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Isobe T, et al. Effects of K-115, a rho-kinase inhibitor, on aqueous humor dynamics in rabbits. Curr Eye Res. 2014 Aug;39 (8) :813-22.|[2]Kaneko Y, et al. Effects of K-115 (Ripasudil), a novel ROCK inhibitor, on trabecular meshwork and Schlemm's canal endothelial cells. Sci Rep. 2016 Jan 19;6:19640.|[3]Yamamoto K, et al. The novel Rho kinase (ROCK) inhibitor K-115: a new candidate drug for neuroprotective treatment in glaucoma. Invest Ophthalmol Vis Sci. 2014 Oct 2;55 (11) :7126-36.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
ROCK1; ROCK2
Citation 01
Adv Sci (Weinh) . 2022 May;9 (13) :e2104682.|Curr Eye Res. 2023 Sep;48 (9) :826-835.|Exp Eye Res. 2024 Jun 18:109977.|Mol Ther. 2023 Jun 7;31 (6) :1846-1856.|Preprints. 2023 May 15.|Science. 2017 Dec 1;358 (6367) :eaan4368.
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