UPF-648 (sodium salt)

UPF-648 sodium salt is an effective inhibitor of kynurenine 3-monooxygenase (KMO), achieving approximately 81% inhibition at a concentration of 1uM, with no inhibitory effect on kynurenine aminotransferase (KAT) .

Product Specifications

CAS Number

[1465017-87-1]

UNSPSC

12352005

Target

Aryl Hydrocarbon Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/UPF-648-sodium-salt.html

Solubility

10 mM in DMSO

Smiles

ClC1=C(Cl)C=CC(C([C@@]2([H])C[C@]2([H])C([O-])=O)=O)=C1.[Na+]

Molecular Formula

C11H7Cl2NaO3

Molecular Weight

281.07

References & Citations

[1]Amori L, et al. On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo. J Neurochem. 2009 Apr;109 (2) :316-25.|[2]Ceresoli-Borroni G, et al. Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications. J Neurosci Res. 2007 Mar;85 (4) :845-54.|[3]Amaral M, et al. Structural basis of kynurenine 3-monooxygenase inhibition. Nature. 2013 Apr 18;496 (7445) :382-5.