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IKD-8344

IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties. It is cytotoxic to L5178Y murine leukemia cells (IC50=0.54 ng/ml) .1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC=6.25 μg/mL) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.

Product Specifications

CAS Number

129046-69-1

UNSPSC

12352005

Target

Fungal

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ikd-8344.html

Smiles

C[C@@H]([C@@](CC1)([H])O[C@@H]1C)[C@@](OC([C@H]([C@@]2([H])O[C@@H](CC([C@@H]([C@](CC3)([H])O[C@]3([H])C4)C)=O)CC2)C)=O)([H])C[C@@]5([H])O[C@]([C@H](C(C[C@@H]6O[C@@]([C@@H](C(O[C@@]4([H])[C@H]([C@@](CC7)([H])O[C@@H]7C)C)=O)C)([H])CC6)=O)C)([H])CC5

Molecular Formula

C48H76O12

Molecular Weight

845.11

References & Citations

[1]Minami, et al. Structure of a novel macrodiolide antibiotic IKD-8344. Tetrahedron Lett. 33 (48), 7373-7376 (1992) .

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

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