GW791343 (trihydrochloride)

GW791343 trihydrochloride is a potent human P2X7 receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human P2X7 receptor, with a pIC50 of 6.9-7.2. GW791343 trihydrochloride can enhance ATP rhythm. GW791343 trihydrochloride can be used in study of neurological disease[1][2].

Product Specifications

CAS Number

[309712-55-8]

UNSPSC

12352005

Target

P2X Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/GW791343-trihydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC(CN2CCNCC2)=CC=C1C)CNC3=CC=C(F)C(F)=C3.[H]Cl.[H]Cl.[H]Cl

Molecular Formula

C20H27Cl3F2N4O

Molecular Weight

483.81

References & Citations

[1]Michel AD, et al. Negative and positive allosteric modulators of the P2X (7) receptor. Br J Pharmacol. 2008 Feb;153 (4) :737-50. |[2]Svobodova I, et al. Circadian ATP Release in Organotypic Cultures of the Rat Suprachiasmatic Nucleus Is Dependent on P2X7 and P2Y Receptors. Front Pharmacol. 2018 Mar 6;9:192.