ARG1 antibody

Background

Arginase-1(Liver arginase) belongs to the arginase family. ARG1 is a novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology and a marker of hepatocytes and hepatocellular neoplasms. ARG1 is closely associated with alternative macrophage activation(PMID:12098359) and ARG1 has been shown to protectmotor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins(PMID: 20071539).It can exsit as a homotrimer(PMID:16141327) and it has 3 isoforms produced by alternative splicing.Defects in ARG1 are the cause of argininemia(ARGIN). Deletion or TNF-mediated restriction of ARG1 unleashes the production of NO by NOS2, which is critical for pathogen control.(PMID:27117406).

Synonyms

Arginase-1|Liver-type arginase|Type I arginase|ARG1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

arginase, liver

Target

ARG1

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, IF, WB

Purification

Immunogen affinity purified

Dilution

WB: 1:500-1:2000; IF: 1:20-1:200

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

CAS Number

9007-83-4

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