F7H
F7H is a Frizzled receptor FZD7 antagonist (IC50: 1.25 μM) . Frizzled receptors (FZDs) influence Wnt signaling, mediating embryonic development and tissue homeostasis. F7H is a potent ligand for the FZD7 transmembrane domain (TMD) [1].
Product Specifications
CAS Number
897109-93-2
UNSPSC
12352005
Target
Wnt
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/f7h.html
Purity
99.42
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C=C1)F)NC2=CC=C(C=C2)SCC(NC3=NC(C4=CC=CC=C4)=CS3)=O
Molecular Formula
C24H18FN3O2S2
Molecular Weight
463.55
References & Citations
[1]Li C, et al. Structure-Based Ligand Discovery Targeting the Transmembrane Domain of Frizzled Receptor FZD7. J Med Chem. 2023 Sep 14;66 (17) :11855-11868.. .
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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