INCB 3284 (dimesylate)

INCB 3284 dimesylate is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM. INCB 3284 dimesylate can be used in the research of acute liver failure.

Product Specifications

CAS Number

[887401-93-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/incb-3284-dimesylate.html

Purity

98.0

Solubility

DMSO : ≥ 83.3 mg/mL

Smiles

O=C(NCC(N[C@H]1CN([C@H]2CC[C@](C3=CC=C(OC)N=C3)(O)CC2)CC1)=O)C4=CC=CC(C(F)(F)F)=C4.CS(=O)(O)=O.CS(=O)(O)=O

Molecular Formula

C28H39F3N4O10S2

Molecular Weight

712.76

Precautions

H302, H315, H319, H335

References & Citations

[1]Xue CB, et al. Discovery of INCB3284, a Potent, Selective, and Orally Bioavailable hCCR2 Antagonist. ACS Med Chem Lett. 2011 Mar 31;2 (6) :450-4.|[2]McMillin M, et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation. 2014 Jul 10;11:121.