Encenicline

Encenicline (EVP-6124) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs) .

Product Specifications

CAS Number

[550999-75-2]

Product Name Alternative

EVP-6124

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/EVP-6124.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC2=C(C(Cl)=CC=C2)S1)N[C@H]3CN4CCC3CC4

Molecular Formula

C16H17ClN2OS

Molecular Weight

320.84

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Prickaerts J, et al. EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors. Neuropharmacology. 2012 Feb;62 (2) :109|[2]Thomas Papouin, et al. Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness. Neuron. 2017 May 17;94:1-15.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 3

Citation 01

Journal of High School Science. 2023 Oct 5.|Psychopharmacology. 2019 Apr;236 (4) :1245-1253.|Eur J Pharmacol. 2017 Sep 15:811:110-116.|Faculty of Health Sciences. 2020 Oct.|Neuron. 2017 May 17;94 (4) :840-854.e7.