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Impurity F of Calcipotriol

Impurity F of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors. IC50 value: Target: Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; Calcipotriol (MC 903; Calcipotriene) exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

Product Specifications

CAS Number

112875-61-3

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

VD/VDR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Impurity-of-Calcipotriol.html

Purity

99.40

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@]1(CCC/2)[C@@](C2=C\C=C3C[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)C\3=C)([H])CC[C@]1([H])[C@H](C)/C=C/[C@H](C4CC4)O

Molecular Formula

C39H68O3Si2

Molecular Weight

641.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Binderup (1993) Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 72 240.|[2]Knutson et al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1a,24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53 829.|[3]Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447.111|[4]Lise Binderup, , Erik Bramm. Effects of a novel vitamin D analogue MC 903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo. Biochemical Pharmacology. Volume 37, Issue 5, 1 March 1988, Pages 889-895

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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