PSI-352938

PSI-352938 (PSI-938) is a hepatitis C virus (HCV) nucleotide inhibitor[1].

Product Specifications

CAS Number

[1199809-32-9]

Product Name Alternative

PSI-938

UNSPSC

12352005

Target

HCV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/PSI-352938.html

Solubility

10 mM in DMSO

Smiles

F[C@]1(C)[C@H](O[P@]2(OC(C)C)=O)[C@@H](CO2)O[C@H]1N3C(N=C(N)N=C4OCC)=C4N=C3

Molecular Formula

C16H23FN5O6P

Molecular Weight

431.36

References & Citations

[1]Lam AM, et al. Hepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA. J Virol. 2011 Dec;85 (23) :12334-42.|[2]Lam AM, et al. Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methylguanosine. Antimicrob Agents Chemother. 2011 Jun;55 (6) :2566-75.