Agerafenib hydrochloride

Agerafenib hydrochloride is a highly potent and orally efficacious inhibitor of BRAFV600E with a Kd of 14 nM.

Product Specifications

CAS Number

[1227678-26-3]

Product Name Alternative

CEP-32496 (hydrochloride) ; RXDX-105 hydrochloride

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Raf

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cep-32496-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=NOC(C(C)(C)C(F)(F)F)=C1)NC2=CC=CC(OC3=C(C=C(OC)C(OC)=C4)C4=NC=N3)=C2.[H]Cl

Molecular Formula

C24H23ClF3N5O5

Molecular Weight

553.92

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Rowbottom MW, et al. Identification of 1- (3- (6,7-dimethoxyquinazolin-4-yloxy) phenyl) -3- (5- (1,1,1-trifluoro-2-methylpropan-2-yl) isoxazol-3-yl) urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E.