Pardoprunox
Product Specifications
UNSPSC Description
Pardoprunox (SLV-308) is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC50s of 8, 9.2, and 6.3, respectively[1].
Target Antigen
5-HT Receptor; Adrenergic Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Pardoprunox.html
Solubility
10 mM in DMSO
Smiles
O=C1OC2=C(N3CCN(C)CC3)C=CC=C2N1
Molecular Weight
233.27
References & Citations
[1]Glennon JC, et al. In vitro characterization of SLV308 (7-[4-methyl-1-piperazinyl]-2(3H)-benzoxazolone, monohydrochloride): a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist. Synapse. 2006 Dec 15;60(8):599-608.|[2]Bronzova J, et al. Double-blind study of pardoprunox, a new partial dopamine agonist, in early Parkinson's disease. Mov Disord. 2010 Apr 30;25(6):738-46.|[3]Bétry C, et al. In vivo effects of pardoprunox (SLV308), a partial D?/D? receptor and 5-HT1A receptor agonist, on rat dopamine and serotonin neuronal activity. Synapse. 2011 Oct;65(10):1042-51.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14958/Pardoprunox-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14958/
Clinical Information
Phase 3
CAS Number
269718-84-5
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
CK-bio-11315-01 48 Tests
Human electron-transfer-flavoprotein beta polypeptide, ETFB ELISA Kit
Ask
View Details CK-bio-11315-02 96 Tests
Human electron-transfer-flavoprotein beta polypeptide, ETFB ELISA Kit
Ask
View Details 
CK-bio-11315-03 5x 96 Tests
Human electron-transfer-flavoprotein beta polypeptide, ETFB ELISA Kit
Ask
View Details 
CK-bio-11315-04 10x 96 Tests
Human electron-transfer-flavoprotein beta polypeptide, ETFB ELISA Kit
Ask
View Details