Tecarfarin (sodium)

Tecarfarin sodium (ATI-5923 sodium) is a novel orally active non-competitive vitamin K epoxide reductase (VKOR) antagonist, impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X[1]. Tecarfarin sodium has the antithrombotic activity[2].

Product Specifications

CAS Number

[1004551-83-0]

Product Name Alternative

ATI-5923 (sodium)

UNSPSC

12352005

Target

VKOR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tecarfarin-sodium.html

Solubility

10 mM in DMSO

Smiles

O=C1C(CC2=CC=C(C(OC(C(F)(F)F)(C)C(F)(F)F)=O)C=C2)=C(O[Na])C3=C(O1)C=CC=C3

Molecular Formula

C21H13F6NaO5

Molecular Weight

482.31

References & Citations

[1]Hobl EL, et al. Tecarfarin: A Novel Vitamin K Antagonist. Thromb Haemost. 2017 Nov;117 (11) :2009-2011.|[2]Bowersox SS, et al. Antithrombotic activity of the novel oral anticoagulant, Tecarfarin [Sodium 3-[4- ((1,1,1,3,3,3-hexafluoro-2-methylpropan-2-yloxy) carbonyl) benzyl]-2-oxo-2H-chromen-4-olate] in animal models. Thromb Res. 2010 Nov;126 (5) :e383-8.