Tecarfarin (sodium)
Tecarfarin sodium (ATI-5923 sodium) is a novel orally active non-competitive vitamin K epoxide reductase (VKOR) antagonist, impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X[1]. Tecarfarin sodium has the antithrombotic activity[2].
Product Specifications
CAS Number
1004551-83-0
Product Name Alternative
ATI-5923 (sodium)
UNSPSC
12352005
Target
VKOR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/tecarfarin-sodium.html
Solubility
10 mM in DMSO
Smiles
O=C1C(CC2=CC=C(C(OC(C(F)(F)F)(C)C(F)(F)F)=O)C=C2)=C(O[Na])C3=C(O1)C=CC=C3
Molecular Formula
C21H13F6NaO5
Molecular Weight
482.31
References & Citations
[1]Hobl EL, et al. Tecarfarin: A Novel Vitamin K Antagonist. Thromb Haemost. 2017 Nov;117 (11) :2009-2011.|[2]Bowersox SS, et al. Antithrombotic activity of the novel oral anticoagulant, Tecarfarin [Sodium 3-[4- ((1,1,1,3,3,3-hexafluoro-2-methylpropan-2-yloxy) carbonyl) benzyl]-2-oxo-2H-chromen-4-olate] in animal models. Thromb Res. 2010 Nov;126 (5) :e383-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
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