Cutamesine

Cutamesine (SA4503) is a potent and selective sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes. Cutamesine shows >100-fold less affinity for the sigma 2 receptor (IC50 of 1784 nM) . Cutamesine has antidepressant effects[1][2].

Product Specifications

CAS Number

[165377-43-5]

Product Name Alternative

SA4503; AGY 94806

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sa4503.html

Purity

99.18

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(CCN2CCN(CCCC3=CC=CC=C3)CC2)C=C1OC

Molecular Formula

C23H32N2O2

Molecular Weight

368.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Lever JR, et al. Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse. 2006 May;59 (6) :350-8. |[2]Ono Y, et al. SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models. Neurosci Lett. 2014 Jan 24;559:174-8.|[3]Minabe Y, et al. Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study. Synapse. 1999 Aug;33 (2) :129-40.