CCT241533

CCT241533 is a potent and selective ATP competitive inhibitor of CHK2 with an IC50 of 3 nM and Ki of 1.16 nM[1].

Product Specifications

CAS Number

[1262849-73-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Checkpoint Kinase (Chk)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cct241533.html

Purity

98.58

Solubility

10 mM in DMSO

Smiles

COC1=C(OC)C=C(C(N[C@H]2[C@H](C(C)(C)O)CNC2)=NC(C3=C(O)C=CC(F)=C3)=N4)C4=C1

Molecular Formula

C23H27FN4O4

Molecular Weight

442.48

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Anderson VE, et al. CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res. 2011 Jan 15;71 (2) :463-72.|[2]Caldwell JJ, et al. Structure-based design of potent and selective 2- (quinazolin-2-yl) phenol inhibitors of checkpoint kinase 2. J Med Chem. 2011 Jan 27;54 (2) :580-90.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Chk1; Chk2

Citation 01

Cell Death Differ. 2021 Jul;28 (7) :2060-2082.|Int J Mol Sci. 2022 Oct 14;23 (20) :12290.|J Chem Inf Model. 2017 Nov 27;57 (11) :2699-2706. |J Cell Biol. 2021 Feb 1;220 (2) :e201911025.