CCT241533
CCT241533 is a potent and selective ATP competitive inhibitor of CHK2 with an IC50 of 3 nM and Ki of 1.16 nM[1].
Product Specifications
CAS Number
1262849-73-9
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cct241533.html
Purity
98.58
Solubility
10 mM in DMSO
Smiles
COC1=C(OC)C=C(C(N[C@H]2[C@H](C(C)(C)O)CNC2)=NC(C3=C(O)C=CC(F)=C3)=N4)C4=C1
Molecular Formula
C23H27FN4O4
Molecular Weight
442.48
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Anderson VE, et al. CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res. 2011 Jan 15;71 (2) :463-72.|[2]Caldwell JJ, et al. Structure-based design of potent and selective 2- (quinazolin-2-yl) phenol inhibitors of checkpoint kinase 2. J Med Chem. 2011 Jan 27;54 (2) :580-90.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk1; Chk2
Citation 01
Cell Death Differ. 2021 Jul;28 (7) :2060-2082.|Int J Mol Sci. 2022 Oct 14;23 (20) :12290.|J Chem Inf Model. 2017 Nov 27;57 (11) :2699-2706. |J Cell Biol. 2021 Feb 1;220 (2) :e201911025.
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
