Talnetant (hydrochloride)

Talnetant (SB 223412) hydrochloride is a selective, competitive, brain-permeable NK3 receptor antagonist with a Ki of 1.4 nM in hNK-3-CHO cells. Talnetant hydrochloride is 100-fold more selective for hNK-3 relative to the hNK-2 receptor and has no affinity for hNK-1. Talnetant hydrochloride can be used in schizophrenia-related studies[1][2][3].

Product Specifications

CAS Number

[204519-66-4]

Product Name Alternative

SB 223412 hydrochloride; SB 223412-A

UNSPSC

12352005

Target

Neurokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/talnetant-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

OC1=C(C(N[C@H](C2=CC=CC=C2)CC)=O)C3=C(N=C1C4=CC=CC=C4)C=CC=C3.[H]Cl

Molecular Formula

C25H23ClN2O2

Molecular Weight

418.92

References & Citations

[1]Giardina GA, et al. Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S) -N- (1-phenylpropyl) -3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412) . J Med Chem. 1999 Mar 25;42 (6) :1053-65.|[2]Houghton LA, et al. Effect of the NK (3) receptor antagonist, talnetant, on rectal sensory function and compliance in healthy humans. Neurogastroenterol Motil. 2007 Sep;19 (9) :732-43.|[3]Dawson LA, et al. In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant) : potential therapeutic utility in the treatment of schizophrenia. Neuropsychopharmacology. 2008 Jun;33 (7) :1642-52.