JNJ-42041935
JNJ-42041935 is a potent, competitive and selective inhibitor of prolyl hydroxylase PHD; inhibits PHD1, PHD2, and PHD3 with pKi values of 7.91±0.04, 7.29 ±0.05, and 7.65±0.09, respectively.
Product Specifications
CAS Number
[1193383-09-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/JNJ-42041935.html
Concentration
10mM
Purity
99.80
Solubility
DMSO : ≥ 36 mg/mL
Smiles
OC(C(C=N1)=CN1C2=NC3=CC(Cl)=C(OC(F)(F)F)C=C3N2)=O
Molecular Formula
C12H6ClF3N4O3
Molecular Weight
346.65
Precautions
H302, H315, H319, H335
References & Citations
[1]Barrett TD, et al. Pharmacological characterization of 1- (5-chloro-6- (trifluoromethoxy) -1H-benzoimidazol-2-yl) -1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase inhibitor. Mol Pharmacol. 2011
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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