JNJ-42041935

JNJ-42041935 is a potent, competitive and selective inhibitor of prolyl hydroxylase PHD; inhibits PHD1, PHD2, and PHD3 with pKi values of 7.91±0.04, 7.29 ±0.05, and 7.65±0.09, respectively.

Product Specifications

CAS Number

[1193383-09-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/JNJ-42041935.html

Concentration

10mM

Purity

99.80

Solubility

DMSO : ≥ 36 mg/mL

Smiles

OC(C(C=N1)=CN1C2=NC3=CC(Cl)=C(OC(F)(F)F)C=C3N2)=O

Molecular Formula

C12H6ClF3N4O3

Molecular Weight

346.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Barrett TD, et al. Pharmacological characterization of 1- (5-chloro-6- (trifluoromethoxy) -1H-benzoimidazol-2-yl) -1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase inhibitor. Mol Pharmacol. 2011