BC1618
Product Specifications
UNSPSC Description
BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation). BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity[1].
Target Antigen
AMPK; E1/E2/E3 Enzyme; Mitophagy
Type
Reference compound
Related Pathways
Autophagy;Epigenetics;Metabolic Enzyme/Protease;PI3K/Akt/mTOR
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bc1618.html
Smiles
OC(COC1=CC=C(C(F)(F)F)C=C1)CN(CC2=CC=CC=C2)CC3=CC=CC=C3
Molecular Weight
415.45
References & Citations
[1]Yuan Liu, et al. A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance. Nat Chem Biol. 2021 Mar;17(3):298-306.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-134656/BC1618-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-134656/BC1618-SDS-MedChemExpress.pdf
CAS Number
2222094-18-8
Available Sizes
Curated Selection
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