Vildagliptin (dihydrate)
Vildagliptin dihydrate (LAF237 dihydrate) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin dihydrate possesses excellent oral bioavailability and potent antihyperglycemic activity[1].
Product Specifications
CAS Number
2133364-01-7
Product Name Alternative
LAF237 (dihydrate) ; NVP-LAF 237 (dihydrate)
UNSPSC
12352005
Target
Apoptosis; Dipeptidyl Peptidase; Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Vildagliptin_dihydrate.html
Solubility
10 mM in DMSO
Smiles
O[C@@]1(C[C@H](C2)C3)C[C@H]3C[C@@]2(NCC(N4CCC[C@H]4C#N)=O)C1.O.O
Molecular Formula
C17H29N3O4
Molecular Weight
339.43
References & Citations
[1]Cheng Q, et al. Combination of the dipeptidyl peptidase IV inhibitor LAF237 [ (S) -1-[ (3-hydroxy-1-adamantyl) ammo]acetyl-2-cyanopyrrolidine] with the angiotensin II type 1 receptor antagonist valsartan [N- (1-oxopentyl) -N-[[2'- (1H-tetrazol-5-yl) -[1,1'-biphenyl]-4-yl]methyl]-L-valine] enhances pancreatic islet morphology and function in a mouse model of type 2 diabetes. J Pharmacol Exp Ther. 2008 Dec;327 (3) :683-91.|[2]Shen M, et al. The synergistic effect of valsartan and LAF237 [ (S) -1-[ (3-hydroxy-1-adamantyl) ammo]acetyl-2-cyanopyrrolidine] on vascular oxidative stress and inflammation in type 2 diabetic mice. Exp Diabetes Res. 2012;2012:146194.|[3]Abdelhamid AM, et al. Vildagliptin/Pioglitazone Combination Improved The Overall Glycemic Control In Type I Diabetic Rats. Can J Physiol Pharmacol. 2018 Mar 6. doi: 10.1139/cjpp-2017-0680.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
DPP-4
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