Tasidotin hydrochloride

Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15, as an inhibitor of microtubule assembly and microtubule dynamics.

Product Specifications

CAS Number

[623174-20-9]

Product Name Alternative

ILX651

UNSPSC

12352005

Hazard Statement

H361-H372

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Tasidotin_(hydrochloride).html

Solubility

10 mM in DMSO

Smiles

[H]Cl.O=C(N1CCC[C@H]1C(NC(C)(C)C)=O)[C@H]2N(C([C@H](C(C)C)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C)=O)=O)C)=O)CCC2

Molecular Formula

C32H59ClN6O5

Molecular Weight

643.30

Precautions

P260-P264-P270-P280-P405-P501

References & Citations

[1]Bai R, et al. Intracellular activation and deactivation of Tasidotin, an analog of dolastatin 15: correlation with cytotoxicity. Mol Pharmacol. 2009 Jan;75 (1) :218-26.|[2]Garg V, et al. Preclinical analysis of Tasidotin HCl in Ewing's sarcoma, rhabdomyosarcoma, synovial sarcoma, and osteosarcoma. Clin Cancer Res. 2007 Sep 15;13 (18 Pt 1) :5446-54.