Sardomozide
Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM.
Product Specifications
CAS Number
149400-88-4
Product Name Alternative
CGP 48664; SAM-486A
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Sardomozide.html
Purity
98.85
Solubility
10 mM in DMSO
Smiles
N=C(C1=CC=CC2=C1CC/C2=N\NC(N)=N)N
Molecular Formula
C11H14N6
Molecular Weight
230.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Regenass U, et al. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res. 1994 Jun 15;54 (12) :3210-7.|[2]Kramer DL, et al. Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664. Cancer Res. 1998 Sep 1;58 (17) :3883-90.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Citation 01
Metabolomics. 2025 Jun 14;21 (4) :82.|SSRN. 2024 Mar 14.|bioRxiv. 2024 Nov 17:2024.08.24.609500.|Cell Rep. 2025 Jan 28;44 (1) :115123.|Cell. 2020 Jun 11;181 (6) :1329-1345.e24.|mSystems. 2024 May 16;9 (5) :e0024624.|Preprints. 2025 May 22.|Sci Adv. 2023 May 19;9 (20) :eade0718.
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