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Quinacrine (dihydrochloride)

Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine dihydrochloride suppresses NF-κB and activate p53 signaling, which results in the induction of the apoptosis[1].

Product Specifications

Product Name Alternative

Mepacrine (dihydrochloride) ; SN-390 (dihydrochloride)

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Autophagy; Mitophagy; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Quinacrine-dihydrochloride.html

Purity

99.38

Solubility

H2O : 13.89 mg/mL (ultrasonic)

Smiles

CC(NC1=C(C=C(OC)C=C2)C2=NC3=CC(Cl)=CC=C31)CCCN(CC)CC.Cl.Cl

Molecular Formula

C23H32Cl3N3O

Molecular Weight

472.88

Precautions

H302

References & Citations

[1]Xiaoyang Wu, et al. Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Curr Ther Res Clin Exp. 2012 Feb;73 (1-2) :52-64.|[2]Anna Eriksson, et al. Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects. Leuk Res. 2017 Dec;63:41-46.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-13735A/Quinacrine-dihydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-13735A/Quinacrine-dihydrochloride-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

Plasmodium

Citation 01

ACS Nano. 2020 Jun 23;14 (6) :7639-7650.|bioRxiv. 2025 Nov 11.|J Biomed Sci. 2025 Feb 5;32 (1) :15.|Part Fibre Toxicol. 2024 Mar 7;21 (1) :13.|Pharmaceutics. 2022 Jan 12;14 (1) :176.|University of Saskatchewan. 2020 Jun 22.|J Neuroinflammation. 2025 Oct 27;22 (1) :243.|Phytomedicine. 2025 Jun 12:145:156981.

CAS Number

[69-05-6]

Available Sizes

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