Fulvestrant (S enantiomer)

Fulvestrant S enantiomer (ICI 182780 S enantiomer) is the S enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM.

Product Specifications

CAS Number

[1316849-17-8]

Product Name Alternative

ICI 182780 (S enantiomer) ; ZD 9238 (S enantiomer) ; ZM 182780 (S enantiomer)

UNSPSC

12352005

Hazard Statement

H360-H362-H413

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Fulvestrant_S_enantiomer.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@@H](O)CC[C@@]1([H])[C@]3([H])[C@H](CCCCCCCCC[S@@](CCCC(F)(F)C(F)(F)F)=O)CC4=C(C=CC(O)=C4)[C@@]3([H])CC2

Molecular Formula

C32H47F5O3S

Molecular Weight

606.77

Precautions

P260-P263-P264-P270-P273-P405-P501

References & Citations

[1]Caprioglio D, et al. An alternative synthesis of the breast cancer drug fulvestrant (Faslodex®) : catalyst control over C-C bond formation. Chem Commun (Camb) . 2015;51 (80) :14866-14868.|[2]Wakeling AE, et al. A potent specific pure antiestrogen with clinical potential. Cancer Res. 1991;51 (15) :3867-3873.