Ezatiostat (hydrochloride)

Ezatiostat hydrochloride (TER199; TLK199 hydrochloride) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat hydrochloride leads to JNK activation by inhibiting GSTP1. Ezatiostat hydrochloride stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat hydrochloride has the potential for myelodysplastic syndrome (MDS) treatment[1][2].

Product Specifications

CAS Number

[286942-97-0]

Product Name Alternative

TER199; TLK199 (hydrochloride)

UNSPSC

12352209

Target

Apoptosis; Glutathione S-transferase

Type

Peptides

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ezatiostat-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(OCC)[C@@H](C1=CC=CC=C1)NC([C@@H](NC(CC[C@H](N)C(OCC)=O)=O)CSCC2=CC=CC=C2)=O.Cl

Molecular Formula

C27H36ClN3O6S

Molecular Weight

566.11

References & Citations

[1]Galili N, et al. Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome. J Hematol Oncol. 2012 May 6;5:20|[2]Ruscoe JE, et al. Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways. J Pharmacol Exp Ther. 2001 Jul;298 (1) :339-45.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

Phase 2

Citation 01

Cancer Biomark. 2025 Oct;42 (10) :18758592251390145.|Adv Sci (Weinh) . 2023 Mar;10 (7) :e2205262.|Arch Biochem Biophys. 2024 Jul:757:110043.|Cell Res. 2018 Dec;28 (12) :1171-1185. |Free Radic Biol Med. 2024 Jun 19:S0891-5849 (24) 00531-8.|Phytomedicine. 2024 Aug 31:134:155989.|Redox Biol. 2023 May:61:102635.|Redox Biol. 2024 Aug 20:76:103323.