Ezatiostat (hydrochloride)
Ezatiostat hydrochloride (TER199; TLK199 hydrochloride) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat hydrochloride leads to JNK activation by inhibiting GSTP1. Ezatiostat hydrochloride stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat hydrochloride has the potential for myelodysplastic syndrome (MDS) treatment[1][2].
Product Specifications
CAS Number
286942-97-0
Product Name Alternative
TER199; TLK199 (hydrochloride)
UNSPSC
12352209
Target
Apoptosis; Glutathione S-transferase
Type
Peptides
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ezatiostat-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(OCC)[C@@H](C1=CC=CC=C1)NC([C@@H](NC(CC[C@H](N)C(OCC)=O)=O)CSCC2=CC=CC=C2)=O.Cl
Molecular Formula
C27H36ClN3O6S
Molecular Weight
566.11
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Phase 2
Citation 01
Frequently Asked Questions
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