(S, R, S) -AHPC-Me-piperazine-acetyl-PIP-AcOH
Selected Variant
HY-161445
Size: 1 Each
(S, R, S) -AHPC-Me-piperazine-acetyl-PIP-AcOH is a conjugate of the VHL ligand and linker of the E3 ubiquitinase VH032. The Linker of (S, R, S) -AHPC-Me-piperazine-acetyl-PIP-AcOH can further be linked to target protein ligands (such as BCR-ABL1) to form PROTAC molecules[1].
Product Specifications
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-r-s-ahpc-me-piperazine-acetyl-pip-acoh.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C2=CC=C([C@@H](NC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CN4CCN(CC(N5CCNCC5)=O)CC4)=O)C(C)(C)C)=O)=O)C)C=C2)SC=N1
Molecular Formula
C35H52N8O5S
Molecular Weight
696.90
References & Citations
[1]Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres. 1236. 2019
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Price
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