(S, R, S) -AHPC-Me-piperazine-acetyl-PIP-AcOH
Selected Variant
HY-161445
Size: 1 Each
(S, R, S) -AHPC-Me-piperazine-acetyl-PIP-AcOH is a conjugate of the VHL ligand and linker of the E3 ubiquitinase VH032. The Linker of (S, R, S) -AHPC-Me-piperazine-acetyl-PIP-AcOH can further be linked to target protein ligands (such as BCR-ABL1) to form PROTAC molecules[1].
Product Specifications
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-r-s-ahpc-me-piperazine-acetyl-pip-acoh.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C2=CC=C([C@@H](NC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CN4CCN(CC(N5CCNCC5)=O)CC4)=O)C(C)(C)C)=O)=O)C)C=C2)SC=N1
Molecular Formula
C35H52N8O5S
Molecular Weight
696.90
References & Citations
[1]Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres. 1236. 2019
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Price
Sign In for Pricing
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
PA1699-APC 100 µg/Vial
Anti-CYP11B1 Antibody Picoband®, APC Conjugate
Sign In for Pricing
View Details 
PB9053-Biotin 100 µg/Vial
Anti-CD34 Antibody Picoband® (Biotine Conjugate)
Sign In for Pricing
View Details 
BNCB3294-100 1x 100 µL
Sarcomeric Actinin Alpha 2 / ACTN2 (ACTN2/3294), Biotin conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940580-500 1x 500 µL
Histone H1 (1415-1), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 