(+) -Apogossypol

(+) -Apogossypol is a pan-BCL-2 antagonist. (+) -Apogossypol binds to Mcl-1, Bcl-2 and Bcl-xL with EC50s of 2.6, 2.8 and 3.69 μM, respectively.

Product Specifications

CAS Number

[66389-74-0]

Product Name Alternative

Apogossypol; NSC736630

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/__addition__-Apogossypol.html

Solubility

10 mM in DMSO

Smiles

OC1=C2C=C(O)C(O)=C(C(C)C)C2=CC(C)=[C@@]1[C@@]3=C(C)C=C4C(C(C)C)=C(O)C(O)=CC4=C3O

Molecular Formula

C28H32O6

Molecular Weight

462.54

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Wei J, et al. Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins. Mol Cancer Ther. 2009 Apr;8 (4) :904-13.|[2]Zhan W, et al. Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo. Mol Med Rep. 2015 Jun;11 (6) :4142-8.