GSK_WRN3
GSK_WRN3 is selective WRN helicase inhibitor (pIC50 = 8.6) . SK_WRN3 can selectively inhibit the growth of microsatellite unstable (MSI) cancer cells, induce DNA damage, and cause cell cycle arrest. GSK_WRN3 has anti-tumor activity[1].
Product Specifications
CAS Number
[2923009-50-9]
UNSPSC
12352005
Target
ATM/ATR; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gsk-wrn3.html
Purity
98.54
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C(NC(C(C(N[C@H]2CS(C=C2)(=O)=O)=O)=C1)=O)C3CCCCC3
Molecular Formula
C16H20N2O5S
Molecular Weight
352.41
References & Citations
[1]Picco G, et al. Novel WRN Helicase Inhibitors Selectively Target Microsatellite Unstable Cancer Cells. Cancer Discov. 2024 Apr 9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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