Talabostat
Talabostat (Val-boroPro; PT100) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC50 Ki = 0.18 nM) and the first clinical inhibitor of fibroblast activation protein (FAP) (IC50 = 560 nM), inhibits DPP8/9 (IC50 = 4/11 nM; Ki = 1.5/0.76 nM), quiescent cell proline dipeptidase (QPP) (IC50 = 310 nM), DPP2, and some other DASH family enzymes. Antineoplastic and hematopoiesis- stimulating activities[1][2][3].
Product Specifications
CAS Number
149682-77-9
Product Name Alternative
Val-boroPro; PT100
UNSPSC
12352005
Target
Dipeptidyl Peptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Talabostat.html
Solubility
DMSO : ≥ 40 mg/mL
Smiles
CC(C)[C@H](N)C(N1[C@H](B(O)O)CCC1)=O
Molecular Formula
C9H19BN2O3
Molecular Weight
214.07
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
DPP-4
Citation 01
Available Sizes
Frequently Asked Questions
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