Tafamidis meglumine

Tafamidis meglumine (Fx-1006A) is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis meglumine inhibits amyloidogenesis[1].

Product Specifications

CAS Number

[951395-08-7]

Product Name Alternative

Fx-1006A

UNSPSC

12352005

Hazard Statement

H360

Target

Transthyretin (TTR)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Tafamidis_meglumine.html

Purity

99.79

Solubility

DMSO : 12.5 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C(C1=CC=C2N=C(C3=CC(Cl)=CC(Cl)=C3)OC2=C1)O.O[C@@H]([C@@H]([C@@H](CO)O)O)[C@@H](O)CNC

Molecular Formula

C21H24Cl2N2O8

Molecular Weight

503.33

Precautions

H360

References & Citations

[1]Bulawa CE, et al. Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proc Natl Acad Sci U S A. 2012 Jun 12;109 (24) :9629-34.