AMPK-IN-3
Product Specifications
UNSPSC Description
AMPK-IN-3 (compound 67) is a potent and selective AMPK inhibitor with IC50s of 60.7, 107 and 3820 nM for AMPK (α2), AMPK (α1) and KDR, respectively. AMPK-IN-3 inhibits AMPK does not affect cell viability or cause significant cytotoxicity in K562 cells. AMPK-IN-3 can be used in study of cancer[1].
Target Antigen
AMPK
Type
Reference compound
Related Pathways
Epigenetics;PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ampk-in-3.html
Solubility
DMSO : 115 mg/mL (ultrasonic)
Smiles
O=C(/C(C1=C2)=C\C3=C(C(C(NCCN(CC)CC)=O)=C(N3)C)C)NC1=CC=C2CCC(N)=O
Molecular Weight
451.56
References & Citations
[1]Matheson CJ, et al. Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors. Eur J Med Chem. 2020 Jul 1;197:112316.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151361/AMPK-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151361/AMPK-IN-3-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2417674-27-0
Available Sizes
Curated Selection
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