Amotosalen (hydrochloride)

Amotosalen hydrochloride (S-59) is a light-activated, DNA-, RNA-crosslinking psoralen compound, which is used to neutralise pathogens. Light-activated Amotosalen binds and permanently crosslinks DNA, preventing replication and thus stopping proliferation of donor T cells. Amotosalen can be used for the study of blood system pathogen reduction technology and graft-versus-host disease (GVHD) [1][2].

Product Specifications

CAS Number

[161262-45-9]

Product Name Alternative

S-59

UNSPSC

12352005

Hazard Statement

H302, H315, H317, H319

Target

DNA/RNA Synthesis; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/amotosalen-hydrochloride.html

Purity

99.86

Solubility

DMSO : 7.14 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

NCCOCC(C1=CC(C(C)=C2)=C3OC2=O)=C(OC1=C3C)C.[H]Cl

Molecular Formula

C17H20ClNO4

Molecular Weight

337.80

Precautions

H302, H315, H317, H319

References & Citations

[1]Amotosalen: Allogeneic Cellular Immunotherapies system, INTERCEPT Plasma System, INTERCEPT Platelet System, S 59. BioDrugs. 2003;17 (1) :66-8.|[2]Lanteri MC, et al. Inactivation of a broad spectrum of viruses and parasites by photochemical treatment of plasma and platelets using amotosalen and ultraviolet A light. Transfusion. 2020 Jun;60 (6) :1319-1331.