CYM-5478
CYM-5478 is a potent and highly selective S1P2 agonist with an EC50 of 119 nM in a TGFα-shedding assay. CYM-5478 protects neural-derived cell lines against Cisplatin toxicity[1][2].
Product Specifications
CAS Number
870762-83-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
LPL Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cym-5478.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=CC(C(F)(F)F)=CN1CC(C2=C(C)N(CC3=CC=CC=C3)C(C)=C2)=O
Molecular Formula
C21H19F3N2O2
Molecular Weight
388.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Deron R Herr, et al. Sphingosine 1-phosphate receptor 2 (S1P2) attenuates reactive oxygen species formation and inhibits cell death: implications for otoprotective therapy. Sci Rep. 2016 Apr 15;6:24541.|[2]Wei Wang, et al. Sphingosine 1-Phosphate Receptor 2 Induces Otoprotective Responses to Cisplatin Treatment. Cancers (Basel) . 2020 Jan 15;12 (1) :211.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
S1PR1; S1PR2; S1PR3; S1PR4; S1PR5
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