PROTAC ER Degrader-3
PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab) [1].
Product Specifications
CAS Number
[2158322-29-1]
UNSPSC
12352005
Target
Estrogen Receptor/ERR; PROTAC-Linker Conjugates for PAC
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-er-degrader-3.html
Solubility
10 mM in DMSO
Smiles
Molecular Formula
C71H77N7O12
Molecular Weight
1220.41
References & Citations
[1]Thomas Pillow, et al. Protac antibody conjugates and methods of use. WO2017201449A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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