KHK-IN-1
KHK-IN-1 (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%) . KHK-IN-1 inhibits the production of F1P in HepG2 cell lysates (IC>sub>50=400 nM) . KHK-IN-1 has potential for the study of diabetes and obesity[1].
Product Specifications
CAS Number
1303469-70-6
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Ketohexokinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/KHK-IN-1.html
Purity
99.00
Solubility
10 mM in DMSO
Smiles
CSC(C=CC=C1)=C1NC2=NC(N3CCNCC3)=NC4=C2N=CN=C4NCC5CC5
Molecular Formula
C21H26N8S
Molecular Weight
422.55
Precautions
H315, H319, H320
References & Citations
[1]Maryanoff BE, et al. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2 (7) :538-43.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
E7845 96 Tests
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) Rat ELISA Kit
Sign In for Pricing
View Details 
IRTAMSCD272PK186CPE100 100 Tests
Anti Mouse CD272 Flow Cytometry Monoclonal Clone PK186 PE Ready To Use 100 Tests
Sign In for Pricing
View Details 133412-PE 100 µL
SLC19A2 (Solute Carrier Family 19 Member 2, Thiamine Transporter 1, THT1, ThTr1, ThTr-1, Thiamine Carrier 1, TC1, THMD1, TRMA) (PE)
Sign In for Pricing
View Details 