KHK-IN-1

KHK-IN-1 (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%) . KHK-IN-1 inhibits the production of F1P in HepG2 cell lysates (IC>sub>50=400 nM) . KHK-IN-1 has potential for the study of diabetes and obesity[1].

Product Specifications

CAS Number

[1303469-70-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Ketohexokinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/KHK-IN-1.html

Purity

99.00

Solubility

10 mM in DMSO

Smiles

CSC(C=CC=C1)=C1NC2=NC(N3CCNCC3)=NC4=C2N=CN=C4NCC5CC5

Molecular Formula

C21H26N8S

Molecular Weight

422.55

Precautions

H315, H319, H320

References & Citations

[1]Maryanoff BE, et al. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2 (7) :538-43.