KHK-IN-1
KHK-IN-1 (compound 8) is a selective and cell membrane permeable ketohexokinase (KHK) inhibitor (IC50=12 nM; F=34%) . KHK-IN-1 inhibits the production of F1P in HepG2 cell lysates (IC>sub>50=400 nM) . KHK-IN-1 has potential for the study of diabetes and obesity[1].
Product Specifications
CAS Number
1303469-70-6
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Ketohexokinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/KHK-IN-1.html
Purity
99.00
Solubility
10 mM in DMSO
Smiles
CSC(C=CC=C1)=C1NC2=NC(N3CCNCC3)=NC4=C2N=CN=C4NCC5CC5
Molecular Formula
C21H26N8S
Molecular Weight
422.55
Precautions
H315, H319, H320
References & Citations
[1]Maryanoff BE, et al. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2 (7) :538-43.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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