SCR7
SCR7 is an unstable form that can be autocyclized into a stable form SCR7 pyrazine. SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity[1][2].
Product Specifications
CAS Number
1533426-72-0
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; CRISPR/Cas9; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SCR7.html
Purity
98.22
Solubility
DMSO : ≥ 45 mg/mL
Smiles
O=C(N1)C(/N=C/C2=CC=CC=C2)=C(NC1=S)/N=C/C3=CC=CC=C3
Molecular Formula
C18H14N4OS
Molecular Weight
334.39
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Available Sizes
Frequently Asked Questions
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